As stated before, the company had already submitted two NDAs to the FDA supporting the use of binimetinib 45 mg twice daily and encorafenib 450 mg once daily for the treatment of patients with BRAF mutant advanced, unresectable or metastatic melanoma. In terms of market opportunity, there are around 200,000 new cases of melanoma diagnosed globally each year of which half have BRAF mutations.Figure 2: Global advanced metastatic melanoma and colorectal cancer markets (Source: Corporate presentation)For the first quarter of 2018, the company reported cash and equivalents of $464.3 million, which included total gross proceeds from the September secondary offering of $258.8 million. Research and development expenses rose slightly to $41.4 million while net loss came in at $38 million.As for near to medium term catalysts for upside, the main one at this point is its PDUFA date on June 30th for the combination of binimetinib and encorafenib in BRAF mutant advanced, unresectable or metastatic melanoma.
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