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As stated before, the company had already submitted two NDAs to the FDA supporting the use of binimetinib 45 mg twice daily and encorafenib 450 mg once daily for the treatment of patients with BRAF mutant advanced, unresectable or metastatic melanoma. In terms of market opportunity, there are around 200,000 new cases of melanoma diagnosed globally each year of which half have BRAF mutations.Figure 2: Global advanced metastatic melanoma and colorectal cancer markets (Source: Corporate presentation)For the first quarter of 2018, the company reported cash and equivalents of $464.3 million, which included total gross proceeds from the September secondary offering of $258.8 million. Research and development expenses rose slightly to $41.4 million while net loss came in at $38 million.As for near to medium term catalysts for upside, the main one at this point is its PDUFA date on June 30th for the combination of binimetinib and encorafenib in BRAF mutant advanced, unresectable or metastatic melanoma.

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iphone 6 plus case The smartphone’s original price is Rs 29,999. During the sale pink glitter phone case glitter mobile cover, only the OnePlus 3T with 6GB RAM and 64GB storage. So, basically, the device gets a price cut of up to Rs 2,000.. To Mikels, his friend met Justin Walters just after finishing high school.The dead cop was a married father of three and his tragic death has shattered his fellow troopers.New York Gov. Andrew Cuomo ordered flags on all government buildings to be flown at half mast in honour of the tragic officer.Davis served as a member of the New York State Police for four years and his death is yet another sad reminder of the risks law enforcement officers face each day in order to protect our communities and serve the residents of this great state, Cuomo said in a statement, adding entire New York family grieves for Davis.State police said Justin Walters, 32, was stationed at nearby Fort Drum, home of the 10th Mountain Division. Military officials said he was a decorated soldier with no previous police record.Walters, of Zeeland, Michigan, was a combat veteran who has served at the post since joining the Army in 2007.He had completed two tours of duty in Afghanistan.Walters surrendered peacefully, clad only in shorts.He has been charged with first degree murder in Davis slaying and second degree murder in Nichole Walters death. iphone 6 plus case

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